newbe help

Being a newbie to script I have a problem that may seem simple but here goes;
When requesting max to run scripts from outside sources I get an error message that says....
Microsoft net framework has blocked the script from running and I must activate permissions.
"Runtime error:.Net runtime exception: an attempt was made to load an assembly from" etc
Not having scripting knowledge, How do I get around this please.
I would be great full thanks Paul!